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Rescuing failed oral implants via Wnt activation

Identifieur interne : 000547 ( Main/Exploration ); précédent : 000546; suivant : 000548

Rescuing failed oral implants via Wnt activation

Auteurs : Xing Yin [République populaire de Chine, États-Unis] ; Jingtao Li [République populaire de Chine, États-Unis] ; Tao Chen [République populaire de Chine, États-Unis] ; Sylvain Mouraret [États-Unis] ; Girija Dhamdhere [États-Unis] ; John B. Brunski [États-Unis] ; Shujuan Zou [République populaire de Chine] ; Jill A. Helms [États-Unis]

Source :

Journal of clinical periodontology [ 0303-6979 ] ; 2016.

RBID : PMC:4973628

Abstract

Aim

Implant osseointegration is not always guaranteed and once fibrous encapsulation occurs clinicians have few options other than implant removal. Our goal was to test whether a WNT protein therapeutic could rescue such failed implants.

Material and Methods

Titanium implants were placed in over-sized murine oral osteotomies. A lack of primary stability was verified by mechanical testing. Interfacial strains were estimated by finite element modelling and histology coupled with histomorphometry confirmed the lack of peri-implant bone. After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated. Quantitative assays were employed to analyse the effects of L-WNT3A treatment.

Results

Implants in gap-type interfaces exhibited high interfacial strains and no primary stability. After verification of implant failure, L-WNT3A or L-PBS injections were initiated. L-WNT3A induced a rapid, significant increase in Wnt responsiveness in the peri-implant environment, cell proliferation and osteogenic protein expression. The amount of peri-implant bone and bone in contact with the implant were significantly higher in L-WNT3A cases.

Conclusions

These data demonstrate L-WNT3A can induce peri-implant bone formation even in cases where fibrous encapsulation predominates.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973628

DOI: 10.1111/jcpe.12503
PubMed: 26718012
PubMed Central: 4973628

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim</title>
<p id="P1">Implant osseointegration is not always guaranteed and once fibrous encapsulation occurs clinicians have few options other than implant removal. Our goal was to test whether a WNT protein therapeutic could rescue such failed implants.</p>
</sec>
<sec id="S2"><title>Material and Methods</title>
<p id="P2">Titanium implants were placed in over-sized murine oral osteotomies. A lack of primary stability was verified by mechanical testing. Interfacial strains were estimated by finite element modelling and histology coupled with histomorphometry confirmed the lack of peri-implant bone. After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated. Quantitative assays were employed to analyse the effects of L-WNT3A treatment.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Implants in gap-type interfaces exhibited high interfacial strains and no primary stability. After verification of implant failure, L-WNT3A or L-PBS injections were initiated. L-WNT3A induced a rapid, significant increase in Wnt responsiveness in the peri-implant environment, cell proliferation and osteogenic protein expression. The amount of peri-implant bone and bone in contact with the implant were significantly higher in L-WNT3A cases.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These data demonstrate L-WNT3A can induce peri-implant bone formation even in cases where fibrous encapsulation predominates.</p>
</sec>
</div>
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Serveur d'exploration sur le patient édenté

Rescuing failed oral implants via Wnt activation

Rescuing failed oral implants via Wnt activation

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Abstract

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